As a new type of two-dimensional nanomaterial, graphene has attracted great attention due to its unique physical properties. Compared with other structures, graphene has extremely high electrical conductivity, thermal conductivity, and excellent mechanical strength; and as a monoatomic planar two-dimensional crystal, graphene has unique advantages in the field of high-sensitivity detection. However, little is known about the interface between graphene and organisms. The study of this issue is crucial for the application of graphene to bioelectronics.
In collaboration with the Lieber Task Force of Harvard University and the Fangying Group of the National Nanoscience Center, the artificial synapses of graphene and animal cardiomyocytes were successfully prepared for the first time. The researchers first obtained nano-processing technology to obtain a high signal-to-noise ratio graphene field effect transistor integrated chip, and then the chicken embryo heart cells were cultured on the chip surface. The study found that stable contact was formed between graphene and single cardiomyocytes, enabling highly sensitive, non-invasive detection of cellular electrophysiological signals. More importantly, for the first time in this study, the shift in the n-type and p-type operating modes of the same graphene device caused by the bias of the gate potential was achieved, and the opposite polarity graphene conductivity signal was obtained in the cell electrophysiological process. It fully proves the electrical nature of measuring biological signals. In addition, the researchers further compared the detection of the same cardiomyocytes by different size graphene biosensors, graphene and silicon nanowire integrated sensing system, and provided theoretical guidance and experimental basis for the development of highly integrated nano-biosensor arrays.
This work establishes a unique research system combining one-dimensional and two-dimensional nanomaterials and cells, which will bring new opportunities for the study of bioelectronics. The relevant results have been published on the Nano Letters in March 2010. The above research work was supported by the Special Fund of the President of the Chinese Academy of Sciences and the National Natural Resources Commission.
In collaboration with the Lieber Task Force of Harvard University and the Fangying Group of the National Nanoscience Center, the artificial synapses of graphene and animal cardiomyocytes were successfully prepared for the first time. The researchers first obtained nano-processing technology to obtain a high signal-to-noise ratio graphene field effect transistor integrated chip, and then the chicken embryo heart cells were cultured on the chip surface. The study found that stable contact was formed between graphene and single cardiomyocytes, enabling highly sensitive, non-invasive detection of cellular electrophysiological signals. More importantly, for the first time in this study, the shift in the n-type and p-type operating modes of the same graphene device caused by the bias of the gate potential was achieved, and the opposite polarity graphene conductivity signal was obtained in the cell electrophysiological process. It fully proves the electrical nature of measuring biological signals. In addition, the researchers further compared the detection of the same cardiomyocytes by different size graphene biosensors, graphene and silicon nanowire integrated sensing system, and provided theoretical guidance and experimental basis for the development of highly integrated nano-biosensor arrays.
This work establishes a unique research system combining one-dimensional and two-dimensional nanomaterials and cells, which will bring new opportunities for the study of bioelectronics. The relevant results have been published on the Nano Letters in March 2010. The above research work was supported by the Special Fund of the President of the Chinese Academy of Sciences and the National Natural Resources Commission.
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